University of Bucharest, Romania
University of Bucharest, Romania
University of Bucharest, Romania and University of Perpignan, France
State University of New York at Binghamton
Silvana Andreescu is the Egon Matijević Endowed Chair in Chemistry and Professor of Bioanalytical Chemistry at Clarkson. She received a PhD in Chemistry, from the University of Perpignan, France, and the University of Bucharest, Romania in 2002, and has been a member of the Clarkson faculty since 2005. Between 2003 and 2005 she was a NSF-NATO postdoctoral fellow at the State University of New York at Binghamton. She is the recipient of a French Government Graduate Fellowship, a NATO-NSF Postdoctoral Fellowship, the NSF-CAREER Award, the John W. Graham Faculty Research Award, the Research Excellence Award and a Member of the Million Dollar Club at Clarkson University, reflecting funds received for sponsored research. In her research lab she has worked with and mentored over 15 graduate students, 4 post-doctoral fellows, 10 international visiting researchers, including a Fulbright Fellow, 3 high school teachers and over 50 undergraduates. She is committed to the success of her students and fellow researchers, many of whom are continuing their education at top graduate institutions or have secured rewarding positions in industry or academia.
- biomolecular recognition of nanoscale materials
- technologies for the immobilization of enzymes and biomolecular receptors
- single-molecule electrochemistry
- microelectrochemical probes for investigations of molecular mechanisms in biological systems
- portable nanoparticle-based assays for food analysis and environmental monitoring
- printable paper-based biosensors and field portable instrumentation
Current Research
Our research interests are in the areas of bioanalytical chemistry, electrochemistry, bionanotechnology, biosensing and environmental nanotechnology. We use modern spectroscopic and electrochemical instrumentation to study molecular level interactions of nanoscale materials, and we design devices that are inexpensive, easy-to-use and have the required detection sensitivity and selectivity for routine applications. Examples of our research projects include:
- field tests that change color within minutes when exposed to toxic chemicals, allowing testers to immediately detect the presence of harmful contaminants in food and environmental samples
- microelectrodes which allow us to study single molecules and measure physiological biomarkers
- electrochemical investigation of engineered nanoparticles and their interactions
New sensing technologies accessible to a broad range of users can substantially improve our measurement capabilities and generate scientific and technological advances for improving the quality of our environmental and, in essence, the quality of human life.
These projects provide students with the opportunity to learn methods for materials characterization, study biomolecular recognition, design their own devices and perform analytical characterization and measurements, all in an effort to address relevant scientific and engineering challenges. Research spans the traditional boundaries of chemistry, materials, biomolecular science and engineering disciplines.
- Research Excellence Award, Clarkson University, 2014
- John W. Graham Jr. Faculty Research Award, Clarkson University, 2011
- NSF-CAREER Award, National Science Foundation (NSF), 2010
- Invited professor, Technological Institute, University of Perpignan, Perpignan, France, 2007
- NSF-NATO Postdoctoral Fellowship Award, NSF, 2003–2004
- EGIDE-CNRS Research Scholarship, France, 2002
- BGF - French Government Doctoral Scholarship, University of Perpignan, France, 1999–2002
- Doctoral Scholarship: University of Bucharest, Faculty of Chemistry, Romania, 1999–2002
- European Community, TEMPUS-MS fellowship: Biosensors for Environmental Control, 1998
E.S. Andreescu, E. Sharpe, D. Andreescu, Portable nanoparticle based assay for rapid detection of food antioxidants (NANOCERAC), WO2014/031633, US2014162368A1. Publication date: 02/27/2014
E.S. Andreescu, M. Ornatska, C. Ispas, D. Andreescu, Reagentless ceria based colorimetric sensor: colorimetric components, methods of use, methods of assembly and related applications, US Patent #US8691520, Patent Pub. No: WO2012170851A3, US20120315659, PCT/US2012/041608, CA2838591A1, EP2718711A2, WO2012170851A3; Publication date: 12/13/2012
Karimi, A. Hayat, S. Andreescu, Biomolecular Detection at ssDNA-Conjugated Nanoparticles by Nano-Impact Electrochemistry, Biosens. Bioelectron., 87, 501-507, 2017. Link to Article
A. Othman, A. Karimi, S. Andreescu, Functional Nanostructures for Enzyme based Biosensors: Properties, Fabrication and Applications J. Mater. Chem B, 45, 7178-7203, 2016. Link to Article
X. Liu, M. Marrakchi, M. Jahne, S. Rogers, S. Andreescu, Real-time investigation of antibiotics-induced oxidative stress and superoxide release in bacteria using an electrochemical biosensor, Free Radical Biology and Medicine, 91, 25-33, 2016. Link to Article
X. Liu, M. Marrakchi, D. Xu, H. Dong, S. Andreescu, Biosensors based on modularly designed synthetic peptides for recognition, detection and live/dead differentiation of pathogenic bacteria Biosens. Bioelectron., 2016, 80, 9-16. Link to Article
G. Bulbul, A. Hayat, S. Andreescu, ssDNA-functionalized nanoceria : A universal redox active aptaswitch for biomolecular recognition, Advanced Healthcare Materials, 5, 7, 822-828, 2016. Link to Article
G. Bulbul, A. Hayat, S. Andreescu, A generic amplification strategy for electrochemical aptasensors using a non-enzymatic nanoceria tag, Nanoscale, 7, 13230-13238, 2015.
R. Alkasir, A. Rossner, S. Andreescu, Portable Colorimetric Paper-Based Biosensing Device for the Assessment of Bisphenol A in Indoor Dust, Environmental Science and Technology, 49, 16, 9889–9897, 2015.
A. Karimi, A. Othman, A. Uzunoglu, L. Stanciu, S. Andreescu, Graphene based Enzymatic Bioelectrodes and Biofuel Cells, Nanoscale, 7, 6909-6923, 2015.
N.P. Sardesai, M. Ganesana, A. Karimi, J.C. Leiter, S. Andreescu, Platinum-doped ceria based Biosensor for in vitro and in vivo monitoring of lactate during hypoxia, Anal. Chem, 87, 5, 2996-3003, 2015.
A. Hayat, S. Andreescu, Nanoceria Particles as Catalytic Amplifiers for Alkaline Phosphatase Assays, Anal. Chem., 85, 21, 10028-10032, 2013.
N. P. Sardesai, D. Andreescu, S. Andreescu, Electroanalytical evaluation of antioxidant activity of cerium oxide nanoparticles by nanoparticle collisions at microelectrodes, J. Am Chem. Soc., 135, 16770-16773, 2013.
E. R. Ozel, R. Alkasir, K. Ray, K. Wallace, S. Andreescu, Comparative Evaluation of Intestinal Nitric Oxide in Embryonic Zebrafish Exposed to Metal Oxide Nanoparticles, Small, 9, 24,1-12, 2013.
E. Sharpe, T. Fresco, D. Andreescu, S. Andreescu, Portable nanoparticle based technology for rapid detection of food antioxidants (NanoCerac), Analyst, 138, 1, 249-262, 2013.
S.J. Ramiz, R. Alkasir, M. Ornatska, S. Andreescu, Colorimetric paper bioassay for the detection of phenolic compounds, Anal. Chem., 84, 9729-9737, 2012.
M. Ornatska, E. Sharpe, D. Andreescu, S. Andreescu, Ceria nanoparticles as colorimetric probes in paper-based bioassays, Anal. Chem. 83, 11, 4273–4280, 2011
Books Edited:
- Nanotechnology for Environmental Decontamination, McGraw-Hill (ISBN 0071702792), Editors: M.K. Ram, S. Andreescu, H. Ding, 448 pages, May, 2011.
- Oxidative Stress: Diagnostics, Prevention, and Therapy, ACS symposium Series, Editors: Silvana Andreescu, Maria Hepel, Volume 1083, November 17, 2011, American Chemical Society, ISBN13: 9780841226838, eISBN: 9780841226845, DOI: 10.1021/bk-2011-1083 http://pubs.acs.org/isbn/9780841226838
- Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2; Editor(s): Maria Hepel, Silvana Andreescu, 1200; October 13, 2015, American Chemical Society, http://pubs.acs.org/isbn/9780841231009