University of Chicago
Hong Kong Baptist University
Hong Kong Baptist University
KaHo Leung received his B.S. degree in Chemistry at Hong Kong Baptist University in 2011. He then pursued his graduate studies at Hong Kong Baptist University. After receiving his Ph.D. degree in November 2015, KaHo joined Prof. Yamuna Krishnan's group at the University of Chicago for postdoctoral research. He joined Clarkson University as an assistant professor in the Department of Chemistry & Biomolecular Science in 2021. His research interest lies in the development of nanodevices for quantitative imaging and application in cell physiology studies. Since starting, KaHo and his team have received grant support from the National Institute of General Medical Sciences. Recently, KaHo was awarded the 2022 Maximizing Investigators' Research Award.
The Leung research group at Clarkson University is an interdisciplinary research team. Using the principles and techniques of Nanotechnology, Chemical Biology and Bioanalytical Chemistry, we develop nanosensors to image specific cellular organelles and elucidate their biological function. The ultimate goal is to leverage new technologies to gain a fundamental understanding of cell physiology and develop new therapies.
Undergraduate students who are interested in gaining research experience in the areas of
- Chemical Biology
- Fluorescence imaging
- Synthesis and Bioconjugation
- Cell culture
should email Professor Leung with a brief description of their research interests and goals.
- Maximizing Investigators' Research Award, 2022
- C.-M. Horejs (Associate Editor of Nature Reviews Materials), Lysosomes uncovered Nature Reviews Materials, 2019, 4, 2.
- Editorial, DNA nanostructures fingerprint cellular organelles Nature Nanotechnology, 2019, 14, 99.
- Researchers use DNA nanomachines to discover subgroups of lysosomes Phys.org https://phys.org/news/2018-12-dna-nanomachines-subgroups-lysosomes.html
N. Narayanaswamy, K. Chakraborty, A. Saminathan, E. Zeichner, K.-H. Leung, J. Devany, Y. Krishnan* A pH-correctable, DNA-based fluorescent reporter for organellar Calcium. Nature Methods, 2019, 16, 95.
- Editorial, DNA nanostructures fingerprint cellular organelles Nature Nanotechnology. 2019, 14, 99.
K.-H. Leung, H.-Z. He, B. He, H.-J. Zhong, S. Lin, Y.-T Wang, D.-L. Ma*, C.-H. Leung*. Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe Chem. Sci., 2015, 6, 2166
K.-H. Leung, B. He, C. Yang, C.-H. Leung*, H.-M. D. Wang*, D.-L. Ma*.“Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation ACS Appl. Mater. Interfaces, 2015, 43, 24046.
K.-H. Leung, H.-Z. He, W. Wang, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*. Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex ACS Appl. Mater. Interfaces, 2013, 23, 12249.