Ka Ho Leung | Clarkson University

Education

Postdoctoral Scholar - 2021
University of Chicago

Chemistry Ph.D. - 2015
Hong Kong Baptist University

Chemistry B.S. - 2011
Hong Kong Baptist University

Courses Taught

CM 302: Forensic Chemistry

CM 305: Biochemistry for Healthcare

Biography

KaHo Leung received his B.S. degree in Chemistry at Hong Kong Baptist University in 2011. He then pursued his graduate studies at Hong Kong Baptist University. After receiving his PhD degree in November 2015, Ka Ho joined Prof. Yamuna Krishnan’s group at the University of Chicago for postdoctoral research. He joined the faculty of Clarkson University as an assistant professor in the Department of Chemistry & Biomolecular Science in 2021. His research interest lies in the development of nanodevices for quantitative imaging and application in cell physiology studies.

Publons Orcid Scopus

Research Interests

The Leung research group at Clarkson University is an interdisciplinary research team. Using the principles and techniques of Nanotechnology, Chemical Biology and Bioanalytical Chemistry, we develop nanosensors to image specific cellular organelles and elucidate their biological function. The ultimate goal is to leverage new technologies to gain a fundamental understanding of cell physiology and develop new therapies.

We are looking for enthusiastic and motivated researchers.

Undergraduate students who are interested in gaining research experience in the areas of

Chemical Biology
Fluorescence imaging
Synthesis and Bioconjugation
Cell culture

should email Professor Leung with a brief description of their research interests and goals.

Publications

Full Publication List in Google Scholar

Selected Publications:

K.-H. Leung, K. Chakraborty, A. Saminathan, Y. Krishnan*, A DNA Nanomachine chemically resolves lysosomes in live cells. Nature Nanotechnology, 2019, 14, 176.

Highlighted in:

C.-M. Horejs (Associate Editor of Nature Reviews Materials), Lysosomes uncovered Nature Reviews Materials, 2019, 4, 2.
Editorial, DNA nanostructures fingerprint cellular organelles Nature Nanotechnology, 2019, 14, 99.
Researchers use DNA nanomachines to discover subgroups of lysosomes Phys.org https://phys.org/news/2018-12-dna-nanomachines-subgroups-lysosomes.html

N. Narayanaswamy, K. Chakraborty, A. Saminathan, E. Zeichner, K.-H. Leung, J. Devany, Y. Krishnan* A pH-correctable, DNA-based fluorescent reporter for organellar Calcium. Nature Methods, 2019, 16, 95.

Highlighted in:

Editorial, DNA nanostructures fingerprint cellular organelles Nature Nanotechnology. 2019, 14, 99.

K.-H. Leung, Y. Krishnan*, Dynamic RNA Nanotechnology Enters the CRISPR Toolbox. ACS Central Science, 2019, 5, 1111.

K. Chakraborty, K.-H. Leung, Y. Krishnan*, High lumenal chloride in the lysosome is critical for lysosome function eLIFE, 2017, 6, e28862.

K.-H. Leung, H.-Z. He, B. He, H.-J. Zhong, S. Lin, Y.-T Wang, D.-L. Ma*, C.-H. Leung*. Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe Chem. Sci., 2015, 6, 2166

K.-H. Leung, B. He, C. Yang, C.-H. Leung*, H.-M. D. Wang*, D.-L. Ma*.“Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation ACS Appl. Mater. Interfaces, 2015, 43, 24046.

K.-H. Leung, H.-Z. He, W. Wang, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*. Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex ACS Appl. Mater. Interfaces, 2013, 23, 12249.