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Ka Ho Leung

Professor Ka Ho Leung

Ka Ho Leung

Assistant Professor
Chemistry & Biomolecular Sci

Email: kleung@clarkson.edu
Phone: 315/268-6559
Office: 133 Science Center
Mailbox: CU Box 5810
Website: Leung Research Group

Department(s): Department of Chemistry and Biomolecular Science
Education
Postdoctoral Scholar - 2021
University of Chicago
Chemistry Ph.D. - 2015
Hong Kong Baptist University
Chemistry B.S. - 2011
Hong Kong Baptist University
Courses Taught
CM 302: Forensic Chemistry
CM 305: Biochemistry for Healthcare
CM 467-95: Direct Research in Biochemistry
CM 890-95: Directed Study in Biochemistry
CM 990-95: Thesis, Dissertation and Special Project
Biography

KaHo Leung received his B.S. degree in Chemistry at Hong Kong Baptist University in 2011. He then pursued his graduate studies at Hong Kong Baptist University. After receiving his Ph.D. degree in November 2015, KaHo joined Prof. Yamuna Krishnan's group at the University of Chicago for postdoctoral research. He joined Clarkson University as an assistant professor in the Department of Chemistry & Biomolecular Science in 2021. His research interest lies in the development of nanodevices for quantitative imaging and application in cell physiology studies. Since starting, KaHo and his team have received grant support from the National Institute of General Medical Sciences. Recently, KaHo was awarded the 2022 Maximizing Investigators' Research Award. 

Publons Orcid Scopus

Research Interests

The Leung research group at Clarkson University is an interdisciplinary research team. Using the principles and techniques of Nanotechnology, Chemical Biology and Bioanalytical Chemistry, we develop nanosensors to image specific cellular organelles and elucidate their biological function. The ultimate goal is to leverage new technologies to gain a fundamental understanding of cell physiology and develop new therapies. 

We are looking for enthusiastic and motivated researchers.

Undergraduate students who are interested in gaining research experience in the areas of 

  • Chemical Biology
  • Fluorescence imaging
  • Synthesis and Bioconjugation
  • Cell culture

should email Professor Leung with a brief description of their research interests and goals.

 

Faculty Accolades

  • Maximizing Investigators' Research Award, 2022
Publications

Full Publication List in Google Scholar

Selected Publications:

K.-H. Leung, K. Chakraborty, A. Saminathan, Y. Krishnan*, A DNA Nanomachine chemically resolves lysosomes in live cells. Nature Nanotechnology, 2019, 14, 176.

Highlighted in:

  • C.-M. Horejs (Associate Editor of Nature Reviews Materials), Lysosomes uncovered Nature Reviews Materials, 2019, 4, 2.
  • Editorial, DNA nanostructures fingerprint cellular organelles Nature Nanotechnology, 2019, 14, 99. 
  • Researchers use DNA nanomachines to discover subgroups of lysosomes Phys.org https://phys.org/news/2018-12-dna-nanomachines-subgroups-lysosomes.html

N. Narayanaswamy, K. Chakraborty, A. Saminathan, E. Zeichner, K.-H. Leung, J. Devany, Y. Krishnan* A pH-correctable, DNA-based fluorescent reporter for organellar Calcium. Nature Methods, 2019, 16, 95.

Highlighted in:

  • Editorial, DNA nanostructures fingerprint cellular organelles Nature Nanotechnology. 2019, 14, 99. 

K.-H. Leung, Y. Krishnan*, Dynamic RNA Nanotechnology Enters the CRISPR Toolbox. ACS Central Science, 2019, 5, 1111.

K. Chakraborty, K.-H. Leung, Y. Krishnan*, High lumenal chloride in the lysosome is critical for lysosome function eLIFE, 2017, 6, e28862.

K.-H. Leung, H.-Z. He, B. He, H.-J. Zhong, S. Lin, Y.-T Wang, D.-L. Ma*, C.-H. Leung*. Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe Chem. Sci., 2015, 6, 2166

K.-H. Leung, B. He, C. Yang, C.-H. Leung*, H.-M. D. Wang*, D.-L. Ma*.“Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation ACS Appl. Mater. Interfaces, 2015, 43, 24046.

K.-H. Leung, H.-Z. He, W. Wang, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*. Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex ACS Appl. Mater. Interfaces, 2013, 23, 12249.

Schools at Clarkson

  • Graduate School
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  • Wallace H. Coulter School of Engineering
  • Earl R. and Barbara D. Lewis School of Health Sciences
  • Institute for a Sustainable Environment
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  • Institute for STEM Education
  • Beacon Institute for Rivers and Estuaries

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