Dr. Woodworth earned a BS in Zoology from the University of Vermont, an MS in Zoology from North Carolina State University, and a Ph.D. in Cell Biology from University of Vermont Medical College. He completed postdoctoral training in molecular virology at Pennsylvania State University College of Medicine. Dr. Woodworth worked for 13 years as a Senior Staff Fellow and then Investigator at the National Cancer Institute. He has been at Clarkson since 2000.
University of Vermont
I study how human papillomaviruses (HPV) contribute to cervical cancer. HPVs are small DNA tumor viruses that often cause warts on the skin and in the anogenital tract. There are over 100 different types of HPV, however, a small subset are termed "high risk" because infection with one of these types represents the major risk factor for cervical cancer. My research has examined the interaction between HPVs and their natural target, the cervical epithelial cell.
Faculty Teaching Excellence Endowed Fund - in Honor of Dr. Robert John McGill and Dr. Nye Smith, 2016
Office of Student Success, Diversity and Inclusion - Faculty Ambassador Award, 2016
Million Dollar Club, Clarkson University, 2013
Kirsten Craig Memorial Faculty Recognition Award for fostering research development of students in the Clarkson University Honors Program, 2006
Outstanding Teacher Award for Clarkson University presented by the Clarkson University Student Association, 2006-2007
(Last six years)
Deng, H., Hillpot, E., Mondal, S., Khurana, K.K., Woodworth, C.D. HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture. Scientific Reports, 2018, (in review)
Deng, H., Hillpot, E., Yeboah, P., Mondal, S., Woodworth, C.D. Susceptibility of epithelial cells cultured from different regions of human cervix to HPV16-induced immortalization. PLoS One, 2018, 13(6):e0199761
Bakshi, S.F., Guz, N., Zakharchenko, A., Deng, H., Tumanov, A.V., Woodworth, C.D., Minko, S., Kolpashchikov, D.M., Katz, E. Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field. Nanoscale, 2018 10:1356-1365
Bakshi, S.F., Guz, N., Zakharchenko, A., Deng, H., Tumanov, A.V., Woodworth, C.D., Minko, S., Kolpashchikov, D.M., Katz, E. Magnetic Field-Activated Sensing of mRNA in Living Cells. J Am Chem Soc., 2017, 139:12117-12120
Guz, N.V., Dokukin, M.E., Woodworth, C.D., Cardin, A., Sokolov, I. Towards early detection of cervical cancer: Fractal dimension of AFM images of human cervical epithelial cells at different stages of progression to cancer. Nanomedicine, 2015, 11:1667-75
Bukhari, M., Deng, H., Jones, N., Towne, Z., Woodworth, C.D., Samways, D.S. Selective permeabilization of cervical cancer cells to an ionic DNA-binding cytotoxin by activation of P2Y receptors. FEBS Lett., 2015, 589:1498-504
Dokukin, M.E., Guz, N.V., Woodworth, C.D., Sokolov, I. Emerging of fractal geometry on surface of human cervical epithelial cells during progression towards cancer. New J Phys., 2015, 17, pii: 033019
Sokolov I, Guz NV, Iyer S, Hewitt A, Sokolov NA, Erlichman JS, Woodworth CD. Recovery of aging-related size increase of skin epithelial cells: in vivo mouse and in vitro human study. PLoS One, 2015, 10:e0122774
Patel, N.G., Kumar, A., Jayawardana, V.N., Woodworth, C.D., Yuya, P.A. Fabrication, nanomechanical characterization, and cytocompatibility of gold-reinforced chitosan bio-nanocomposites. Mater Sci Eng C Mater Biol Appl., 2014, 44:336-44
Palantavida, S., Guz, N.V., Woodworth, C.D., Sokolov, I. Ultrabright fluorescent mesoporous silica nanoparticles for prescreening of cervical cancer. Nanomedicine, 2013 9:1255-62
Iyer, S.K., Gaikwad. R,M,, Woodworth. C.D., Volkov, D.O., Sokolov, I. Physical Labeling of Papillomavirus-Infected, Immortal, and Cancerous Cervical Epithelial Cells Reveal Surface Changes at Immortal Stage. Cell Biochem Biophys. 2012, 63:109-16.
Vandermark, E.R., Deluca, K.A., Gardner, C.R., Marker, D.F., Schreiner, C.N., Strickland, D.A., Wilton, K.M., Mondal, S., Woodworth, C.D. Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization. Virology, 2012, 425:53-60