Jan Scrimgeour

Biography

Currently, my work focuses on the effect of fluids flow in defining the structure and biological function of the biopolymer brushes found on the surface of the blood vessel wall. This structure is just one example of the cell surface expression of the large polymer hyaluronan that the cell uses to define the properties of cell-fluid and cell tissue interfaces.

Education Background

Physics Ph.D. - University of Oxford
Optoelectronics and Laser Engineering M.S. - Heriot-Watt University

Experience

Assistant Professor Department of Physics, Clarkson University, 2013-present
Postdoctoral Fellow Department of Physics, Georgia Institute of Technology, 2008-2013

Courses Taught

PH141 - Physics for Life Sciences I
PH142 - Physics for Life Sciences II
PH323 - Optics
PH341 - Solid State Physics
PH320 - Physical Models of Living Systems
PH426 - Intro to Biophysics
PH451 - Statistical Mechanics I

Research Interests

Cell physics
Soft materials
Tissue engineering
Advanced microscopy

Awards

National Science Foundation CAREER Award 2019
Clarkson Ignite Fellowship, 2018
Outstanding New Teacher Award Clarkson University 2017

Publications

Driving Complex Flow Waveforms with a Linear Voice Coil Actuator D. C. Young, J. M. Brehm, and J. Scrimgeour Biomicrofluidics, 13, 034101 (2019)
Adhesion and Mechanical Properties of P-selectin PSGL-1 Bonds B. Farzi, D. C. Young, J. Scrimgeour, and C. Cetincaya Colloids and Surfaces B: Biointerfaces, 173, 529 (2019)
Adhesion and Stiffness of Biotin-Superavidin Bonds B. Farzi, J. Scrimgeour, and C. Cetincaya Colloids and Surfaces B: Biointerfaces, 171, 308 (2018)
Optimizing Likelihood Models for Particle Trajectory Segmentation in Multi-State Systems D. C. Young and J. Scrimgeour Physical biology, 15(6), 066003 (2018)
Incorporation of Soft Shaped Hydrogel Sheets into Microfluidic Systems using a Simple Adhesion Masking Process D. C. Young, I. G. Newsome and J. Scrimgeour Appl. Phys. Lett. 111, 263705 (2017)
Single-Molecule Imaging of Proteoglycans in the Pericellular Matrix J. Scrimgeour, L. T. McLane, P. S. Chang, and J. E. Curtis Biophys. J. 113, 2316 (2017)
Cell Surface Access Is Modulated by Tethered Bottlebrush Proteoglycans P. S. Chang, L. T. McLane, R. Fogg, J. Scrimgeour, J. S. Temenoff, A Granqvist, and J. E. Curtis Biophys. J. 110, 2739 (2016)
A Fast Weighted Centroid Algorithm for Single Particle Localization Near the Information Limit J. Fish and J. Scrimgeour Appl. Opt. 54, 6140 (2015)
Speed Dependence of Thermochemical Nanolithography for Gray-Scale Patterning K. M. Carroll, M. Desai, A. J. Giordano, J. Scrimgeour, W. P. King, E. Riedo, and J. E. Curtis ChemPhysChem, 15, 2530 (2014)
K. M. Carroll, A. J. Giordano, D. Wang, V. K. Kodali, J. Scrimgeour, W. P. King, S. R. Marder, E. Riedo, and J. E. Curtis, “Fabricating Nanoscale Chemical Gradients with ThermoChemical NanoLithography”, Langmuir, 29, 2013, 8675–8682.
D. W. Dumbauld, T. T. Lee, A. Singh, J. Scrimgeour, C. A. Gersbach, E. A. Zamir, J. Fu, C. S. Chen, J. E. Curtis, S. W. Craig, A. J. García. “How Vinculin Regulates Force Transmission”, PNAS, May, 2013; doi: 10.1073/pnas.1216209110.
L. T. McLane, P. Chang, A. Granqvist, H. Boehm, A. Kramer, J. Scrimgeour, J. E. Curtis, “Spatial Organization and Mechanical Properties of the Pericellular Matrix on Chondrocytes”, Biophysical Journal, 104, 2013, 986-996,
J. Scrimgeour, A. San Miguel, J. E. Curtis, S. H. Behrens. “A Generalized Approach for Measuring Microcapsule Permeability with Fluorescence Recovery After Photobleaching”, Journal of Materials Science, 48, 2013, 2215-2223.
J. Scrimgeour and J. E. Curtis. “Aberration Correction in Wide-field Fluorescence Microscopy by Segmented-Pupil Image Interferometry”, Optics Express 20(13), 14534 (2012). Selected for The Virtual Journal for Biomedical Optics 7(8) (2012).
J. Scrimgeour, J,-K Cho, V. Breedveld and J. E. Curtis. “Microfluidic dialysis cell for characterization of macromolecule interactions”, Soft Matter 7, 4762 (2011).
V. Kodali, J. Scrimgeour, S. Kim, J. H. Hankinson, W. A. de Heer, C. Berger, and J. E. Curtis. “Non-Perturbative Chemical Modification of Graphene for Protein Micropatterning”, Langmuir 27, 863 (2011).
A. San Miguel, J Scrimgeour, J. E. Curtis and S. H. Behrens, “Smart Colloidosomes with Tunable Permeability and Dissolution Trigger”, Soft Matter 6, 3163 (2010).
J. Scrimgeour, V. Kodali, D. Kovari, and J. E. Curtis. “Photobleaching- Activated Chemical Micropatterning on Self-Assembled Monolayers”, J. Phys.: Condens. Matter 22, 194103 (2010).
E. Eriksson, K. Sott, F. Lundqvist, M. Sveningsson, J. Scrimgeour, D. Hanstorp, M. Goksör and A. Granéli. “A microfluidic device for reversible environmental changes around single cells using optical tweezers for cell selection and positioning”, Lab on a Chip 10, 610 (2010).
E. Eriksson, D. Engstrom, J. Scrimgeour and M. Goksör. “Automated focusing of nuclei for timelapse experiments on single cells using holographic optical tweezers”, Optics Express 17, 5585 (2009). Selected for The Virtual Journal for Biomedical Optics 4(5) (2009).
U. Mirsaidov, J. Scrimgeour, W. Timp, K. Beck, M. Mir, P. Matsudaira, and G. Timp. “Live Cell Lithography: Using optical tweezers to create synthetic tissue”, Lab on a Chip 8, 2174 (2008). Selected for the Virtual Journal Chemical Biology Research Articles,1(2009).
A. Högele, S. Seidl, M. Kroner, K. Karrai, C. Schulhauser, O. Sqalli, J. Scrimgeour, and R. J. Warburton. “Fiber-based confocal microscope for cryogenic spectroscopy”, Rev. Sci. Instrum. 79, 023709 (2008).
E. Eriksson, J. Scrimgeour, A. Granéli, K. Ramser, R. Wellander, J. Enger, D. Hanstorp and M. Goksör. “Optical Manipulation and Microfluidics for Studies of Single Cell Dynamics”, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
J. Scrimgeour, D. N. Sharp, C. F. Blanford, O. M. Roche, R. G. Denning and A. J. Turberfield, “Three-Dimensional Optical Lithography for Photonic Microstructures”, Advanced Materials 18(12) 1557 (2006).
J. S. King, E. Graugnard, O. M. Roche, D. N. Sharp, J. Scrimgeour, R. G. Denning, A. J. Turberfield, and C. J. Summers, “Infiltration and Inversion of Holographically-Defined Polymer Photonic Crystal Templates by Atomic Layer Deposition”, Advanced Materials 18(12) 1561 (2006).
K. H. Lee, A. M. Green, R. A. Taylor, D. N. Sharp, J. Scrimgeour, O. M. Roche, J. H. Na, A. F. Jarjour, A. J. Turberfield, F. S. F. Brossard, D. A. Williams and G. A. D. Briggs. “Registration of single quantum dots using cryogenic laser photolithography”, Applied Physics Letters 88, 193106 (2006).

Book Chapters

G. Timp, U. Mirsaidov, W. Timp, J. Shim, D. Wang, V. Dimitrov, J. Scrimgeour, C. Lin, J, Comer, A. H. Ho, X. Zou, A. Aksimentiev, and K. Shulten, “Third Generation DNA Sequencing with a Nanopore.” Nanopores: Sensing and Fundamental Biological Interactions (2011).
J. Scrimgeour, E. Eriksson and M. Goksör, “Laser Surgery and optical trapping in a laser scanning microscope”, Methods in Cell Biology: Laser manipulation of Cells and Tissues. (2007).