CAMP December Newsletter: Page 5
Professor Melman’s Research Uses Medicinal Chemistry to Fight Diseases
Professor Artem Melman, of Clarkson University’s Department of Chemistry & Biomolecular Science, specializes in synthetic organic and medicinal chemistry with particular emphasis on processes involving transition metal cations. He works on fighting diseases through regulation of iron metabolism, including development of new methods of treatment of cancer through administration of chemical chelators that sequester and excrete iron cations necessary for growth of cancer cells. Resultant iron chelators selectively inhibit growth of cancer cells that are dependent on large amounts of iron without toxic effect on normal cells. In the field of biomaterial research he develops new biocompatible photoresponsive hydrogels using natural carbohydrate biopolymers cross-linked with metal cations which are dissolved through exposure to visible light under conditions that are sufficiently mild to allow survival and growths of livings cells. See Figure 4. Development of these biomaterials paves the road to the use of photolithographic methods for cell cultures and tissue engineering applications. In the field of development of new synthetic methodologies, Professor Melman develops new approaches for in vivo chemical modification of proteins synthesized in cells to monitor their biosynthesis, transport, and binding of other proteins.
FIGURE 4: Biocompatible iron cross-linked carbohydrate based hydrogels allow application of photolithography, a staple technology used in microelectronics, for sophisticated patterning of growing cell cultures needed for tissue engineering.
Professor Melman (who has been at Clarkson since 2008) received his doctoral degree in Chemistry from Weizmann Institute of Science in Israel. He worked as a postdoctoral researcher in Dyson-Perrins at the University of Oxford, as a lecturer at the Hebrew University of Jerusalem, and as a research fellow at the National Institute of Diabetes, Digestive & Kidney Diseases.
Professor Cetin Cetinkaya (of Clarkson University’s Department of Mechanical & Aeronautical Engineering) and his team have developed a nonlinear model for the motion of an adhesive particle on a vibrating substrate. See Figure 5. The long-term objective of this research program is to develop technologies required for non-contact adhesion characterization and adhesion mapping on the surface of micro-scale objects. They observed that some spherical micro-particles on a vibrating flat substrate not only have their predicted rocking resonance frequencies, but also have other resonance peaks at their doubles. The group determined that the frequency doubling is caused by nonlinear coupling between the out –of-plane and rocking modes of motion, and whirling-like motion that must be present for the doubling effect to occur. Also they found that the work –of-adhesion values (extracted from the experimental resonance frequencies of a set of particles using the developed model) are in good agreement with those reported in the literature. The current focus is on incorporating this mathematical formulation to a particle manipulation system based on surface acoustic waves for surface adhesion mapping at the micro-scale.
FIGURE 5: Schematics of the measurement zone of the base excitation experimental setup (close up).