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CAMP and the Wallace H. Coulter School of Engineering Co-Sponsor Shipley Lectures

University Professor Gabor A. Somorjai, of the Department of Chemistry at the University of California - Berkeley, presented Shipley Lectures at Clarkson University on October 21, 2002 and October 22, 2002. Professor Somorjai is considered the father of modern surface chemistry. He was one of fifteen scientists named by President George W. Bush as recipients of the 2002 National Medal of Science, the Nation's highest honor for lifetime achievement in fields of scientific research. Professor Somorjai's Shipley presentations included "Surfaces: Favorite Media of Evolution and New Technologies," and "The Evolution of Surface Chemistry and Catalysis from the Time of Langmuir and Taylor to the 21st Century." These lectures were co-sponsored by CAMP and the Wallace H. Coulter School of Engineering.

From left: Clarkson University Provost Anthony Collins, University Professor Gabor A. Somorjai (University of California at Berkeley), Clarkson University President Denny Brown, and Professor Egon Matijevic' (the Victor K. LaMer Chair in Colloid and Surface Science).

University Professor Gabor Somorjai (right) converses with Clarkson University Provost Anthony Collins (left) and Clarkson University Vice Provost /CAMP Director S.V. Babu (center).

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Data are also being collected on the effect of complexation on the shifts in carbon NMR peaks. Powell, with the help of Doctors William Lenhart and Brian Antalek at Eastman Kodak Company (a CAMP corporate Sponsor), carried out the preliminary experiments which showed the direction and magnitude of the shifts due to complexation of the carboxamide receptor mentioned above with donor 2,6-dimethylaniline (2,6-DMA), the latter being a model compound for toxic bupivacaine (cf. Fig 1). The data shows that the changes in chemical shifts upon complexation are dependent on donor concentration; and, the changes are not the same for the different carbons in either the acceptor or donor (Table 2). The carbon atom positions listed in the Table are shown in Figure 2. It is interesting to note that the effect of donor concentration on the change in chemical shift of the carbonyl carbon in the receptor is three times the effect on other carbons in the molecule. Binding energies using the shifts for each carbon, calculated by a method published previously by others, ranged from -1500 to -3600 J/mol. An example of a plot is shown in Figure 3.

The researchers will obtain more detailed NMR information on these chemical systems using both Kodak and Clarkson/CAMP instrumentation with the goal of comparing the shift data to uptake of a toxin as measured by HPLC or other analytical method. Ultimately it is hoped that some deduction can be made as to what the preferred rotational configuration the two rings shown in Figure 2 might have with respect to each other, and why the changes in shifts differ for the carbon atoms in both the acceptor and donor molecules.

For more information about Professor Partch and his research, please call him at 315-268-2351 or send email to partch@clarkson.edu.