CAMP Annual Report: Page 8
Research Assistant Professor Dr. Jan Halamek
|Research Assistant Professor Dr. Vera Bocharova|
This innovative paradigm would enable injury gates to be interchanged as needed for different battlefield conditions. It represents a substantial development in the bioprocessing capabilities of the biocomputing logic gate systems. The results have been published (Analyst 2010, vol.135, pages 2249-2259) and highlighted at the website of the Royal Society of Chemistry (UK): http://www.rsc.org/Publishing/Journals/cb/Volume/
2010/09/logical_injury_assessment.asp. Dr. Halámek has been invited with a plenary lecture to the 2010 International Symposium on Spectral Sensing Research at Fort Leonard Wood, MO, to describe the results of the study. The innovative research is conducted within the framework of the project supported by a multi-million dollar award from the Office of Naval Research. This work is being carried out under the general supervision of Professor Evgeny Katz as part of a CAMP program at Clarkson University.
A novel switchable biocatalytic interface has been designed by a team of students headed by Research Assistant Professor Dr. Vera Bocharova. A nanostructured biocatalytic interface reversibly gating electrochemical reactions upon chemical signals processed by immobilized enzymes was a goal of the project. The chemical signals were converted to local interfacial pH changes causing restructuring of the stimuli-responsive polymer and switching ON–OFF the electrochemical reaction. The switchable interface represents the first example of a fully functional integrated nanostructured system composed of the biocatalytic entities transducing the chemical signals into pH changes and the gating polymer responding to the local pH value by its restructuring. The results of the work were published in a prestigious international journal (Chem. Commun. 2010, vol. 46, pages 2088-2090). The present result opens the way to enzymatically controlled biochemical interfaces for various biotechnological applications. The system complexity could be scaled up to a multi-enzyme ensemble processing many biochemical signals and resulting in future implantable bioelectronic devices with interfaces controlled by physiological concentrations of biochemicals. The team (advised by Dr. Bocharova) continues the work to apply the developed approach for drug release controlled by external biochemical signals. This project is one of the most important directions being taken within the framework of the multi-million dollar program sponsored by the Office of Naval Research. The research is being performed under the general supervision of Professor Evgeny Katz as part of a CAMP program at Clarkson University.
Chemistry and Biomolecular Science Professor Silvana Andreescu is working on the development, characterization, and applications of advanced materials for next generation biomedical and biosensing applications for environmental, food, and clinical monitoring. Examples include biomedical sensors for in vivo and in vitro monitoring of clinical analytes, nanoparticle-induced toxicity, and oxidative stress. In a collaborative project with Professor Kenneth Wallace (of the Biology Department at Clarkson) she is using bioanalytical microsensors to study in vivo toxicity of fine particles on zebra fish embryos. Professor Andreescu hopes to determine the mechanism of the cytotoxic response at the organ level and provide a testing platform for nanotoxicity assessment that could be used to predict toxicity and anticipate environmental and health risks.
Dr. Selma Mededovic Thagard Joins Clarkson University’s Faculty
Assistant Professor Dr. Selma Mededovic Thagard
Dr. Selma Mededovic Thagard is a new faculty member at Clarkson University, where she serves as an Assistant Professor in the Department of Chemical and Biomolecular Engineering. She received a doctoral degree in Chemical Engineering from Florida State University in 2006. Professor Thagard was a Research Scientist for the Department of Ecological Engineering at Toyohashi University in Japan from August 2007 – April 2009 and did postdoctoral work in the Department of Chemistry at Colorado State University. She is a member of the American Institute of Chemical Engineers. Her areas of research interest include the following.
1. Non-Thermal Plasma for Air and Wastewater Treatment
2. Plasma-Assisted Material Synthesis and Plasma Etching from the Liquid Phase
3. Mathematical Modeling of Electrical Discharges in Gases and Liquids
Professor Ian Suni
In April 2010, the New York State Education Department (NYSED) approved a new Ph.D. program in Materials Science and Engineering at Clarkson University. This new Ph.D. program builds upon the extensive Materials expertise developed by CAMP faculty since CAMP’s inception in 1987. The Ph.D. program includes two required courses, four courses chosen from one of two focus areas (Nanotechnology, Biomaterials and Advanced Materials), and four elective courses. Ph.D. applications are currently being accepted, including applications from industrial researchers. These doctoral students will be mentored by CAMP faculty. The Director of the new Materials Science and Engineering Ph.D. program is Professor Ian Suni, from the Department of Chemical and Biomolecular Engineering. He will work closely with CAMP Director S.V. Babu.