Postdoctoral, University of California at Berkeley, 2012
Postdoctoral, Emory University, 2009
Ph.D., Rice University, 2008
M.S., Tsinghua University, 2002
B.S., Tsinghua University, 1999
Our research program lies at the interface of chemistry, materials science and biology with an emphasis on the molecular self-assembly of soft matter nanomaterials. Current research is primarily focused on the supramolecular assemblies based on peptides/polypeptides, proteins, and block-copolymers. The goal is to fundamentally understand the specific molecular interactions involved in the natural assembly and utilize the knowledge acquired to guide the synthesis and assembly of man-made materials to suit a wide range of applications in drug and gene delivery, tissue engineering, light harvesting, molecular transport and sensing. To accomplish the goal, we will employ a multi-disciplinary approach through combining de novo designed peptides and synthetic polymers to generate functional hybrid materials with well-defined hierarchical structures. We are also interested in understanding the static and dynamic interactions involved in a multi-component system to facilitate rational design and synthesis of more complex, smart materials with desired stimuli responsiveness. While our research emphasis is on the soft matter assembly, we also seek to integrate the study of inorganic colloid materials into our programs to broaden the utility of these hybrid materials in biominerallization and pattering of inorganic nanoparticles.
Given the nature of our multi-disciplinary research, students are encouraged to apply from diverse scientific disciplines. Students will be exposed to a wide range of skills and techniques in peptide design, combination of solid/solution synthetic methods and chromatography separation as well as an array of spectroscopy and microscopy methods for material characterization including NMR, Masspec, IR, fluorescence, DSC, SEM, TEM, Cryo-genic TEM and X-ray diffraction.
- Dawei Xu, Derek Dustin, Linhai Jiang, Damien, S. K. Samways, He Dong*, “Designed Filamentous Cell Penetrating Peptides: Probing Supramolecular Structure-Dependent Membrane Activity and Transfection Efficiency”, Chem. Commun., 2015, 51, 11757-11760. (Featured on Front Cover)
- He Dong, Reider Lund, Ting Xu, “Micelle Stabilization via Entropic Repulsion: Balance of Force Directionality and Geometric Packing of Subunit”, Biomacromolecules, 2015, 16, 743-747.
- Dawei Xu, Linhai, Jiang, Anju Singh, Miao Yang, Derek Dustin, Ling, Liu, Reidar Lund, Timothy Sellati, He Dong*, “Designed Supramolecular Filamentous Peptides: Balance of Nanostructure, Cytotoxicity and Antimicrobial Activity”, Chem. Commun., 2015, 51, 1289-1292.
- Nikhil Dube, Jai Seo, He Dong, Jessica Shu, Reidar Lund, Lisa Mahakian, Katherine Ferrara, Ting Xu, “Effect of Core Composition of 3-Helix Micelles on Cargo Encapsulation Stability and Pharmacokinetics”, Biomacromolecules, 2014, 15, 2963-2970.
- Geng Li, Jun Wu, Xu Qin, Jianhui Zhu, Kodandaraman Viswanathan, He Dong, P. Somasundaran, Richard A. Gross, “Chemo-enzymatic Routes to Lipopeptides and Their Colloidal Properties”, Langmuir, 2014, 30, 6889-6896.
- Miao Yang, Dawei Xu, Linhai Jiang, Lin Zhang, Derek Dustin, Reidar Lund, Ling Liu, He Dong*, “Filamentous Supramolecular Peptide-Drug Conjugates as Highly Efficient Drug Delivery Vehicles”, Chem. Commun., 2014, 50, 4827-3832.
- Bin Cao, Linlin Li, Haiyan Wu, Qiong Tang, Bingbing Sun, He Dong, Jiang Zhe, Gang Cheng, “Zwitteration of Dextran: A Facile Route to Integrate Antifouling, Switchability and Optical Transparency into Natural Polymers”, Chem. Commun., 2014, 50, 3234-3237.
- Nikhil Dube, Jessica Y. Shu, He Dong, Jai W. Seo, Elizabeth Ingham, Azadeh Kheirolomoom, Pin-Yuan Chen, John Forsayeth, Krystof Bankiewicz, Katherine W. Ferrara, Ting Xu, “Evaluation of DOX-Loaded 3-Helix Micelles as Nanocarriers”, Biomacromolecules, 2013, 14 (10), 3697–3705.
Before joining Clarkson University
- He Dong, Jessica Y. Shu, Nikhil Dube, Yufei Ma, Matthew V. Tirrell, Kenneth H. Downing, Ting Xu, “3-Helix Micelles Stabilized by Polymer Springs”, J. Am. Chem. Soc., 2012, 134, 11807-11814.
- He Dong, Nikhil Dube, Jessica Y. Shu, Jai W. Seo, Lisa M. Mahakian, Katherine W. Ferrara, Ting Xu, “Long Circulating Micelles Based on Helix-Bundle Forming Peptide-Polymer Conjugates”. ACS Nano, 2012, 6, 5320-5329.
- He Dong, Xuezheng Song, Yi Lasanajak, Richard D. Cummings, Elliot L. Chaikof, “Facile Construction of Fluorescent Peptide Microarrays: One-step Fluorescent Derivatization of Sub-Microscale Peptide Aldehydes for Selective Terminal Immobilization”. Anal. Biochem., 2010, 398, 132-134.
- Lorenzo Aulisa, He Dong, Jeffrey, D. Hartgerink. “Self-assembly of Multidomain Peptides: Sequence Variation Allows Control Over Crosslinking and Viscoelasticity”. Biomacromolecules 2009, 10, 2694-2698.
- He Dong, Sergey, E. Paramonov, Jeffrey, D. Hartgerink, “Self-assembly of Alpha-Helical Coiled Coil Nanofibers”, J. Am. Chem. Soc. 2008, 130, 13691-13695.
- Hoo-Wok, Jun, Sergey, E. Paramonov, He Dong, Jeffrey, D. Hartgerink, “Enzyme-Mediated Degradation of Peptide-Amphiphile Nanofiber Networks”, Journal of Biomaterial Research, Polymer Ed., 2008, 19, 665-676.
- He Dong, Sergey, E. Paramonov, Lorenzo, Aulisa, Erica Bakota, Jeffrey, D. Hartgerink “Self-Assembly of Multi-Domain Peptides: Balancing Molecular Frustration Controls Conformation and Nanostructure”, J. Am. Chem. Soc. 2007, 129, 12468-12471.
- He Dong, Jeffrey, D. Hartgerink, “Investigation of Role of Hydrophobic Clusters on Coiled Coils in Inducing Alpha to Beta Secondary Structural Conversion”, Biomacromolecules, 2007, 8(2), 617-623.
- He Dong, Jeffrey, D. Hartgerink, “Short Helical Coiled Coil Homodimer and Heterodimer”, Biomacromalecules, 2006, 7(3), 691-695.
Current research group members
Dawei Xu (PhD student)
Linhai Jiang (PhD student)
Maureen Hoen (undergraduate student)
Brendan J. Elmore (undergraduate student)
Louis DeRidder (undergraduate student)