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Silvana Andreescu

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Andreescu

Egon Matijević Chair of Chemistry
Professor of Chemistry & Biomolecular Science

Department of Chemistry and Biomolecular Science, Clarkson University
8 Clarkson Avenue, Potsdam, NY 13699-5810

Phone: 315-268 2394; Fax: 315-268 6610
E-mail: eandrees@clarkson.edu

 


Educational Background

NATO-NSF Postdoctoral Fellowship, State University of New York at Binghamton
Ph.D. Chemistry, University of Perpignan, France and University of Bucharest, Romania
MS Biosensors, University of Bucharest, Romania
BS Chemistry, University of Bucharest, Romania


Awards

- Million Dollar Club, Clarkson University, 2012
- John W. Graham Jr. Faculty Research Award, Clarkson University, 2011
- NSF-CAREER award, National Science Foundation (NSF), 2010
- Invited professor, Technological Institute, University of Perpignan, Perpignan, France, 2007
- NSF-NATO postdoctoral fellowship award, NSF, 2003–2004
- EGIDE-CNRS Research Scholarship: Centre National de Recherche Scientifique, France, 2002
- European Community, BIOSET Collaboration Program: Environment and Climate, 2000
- BGF - French Government Doctoral Scholarship, Bourse de Recherche-Cotutelle: Centre de Phytopharmacie, University of Perpignan, Perpignan, France, 1999–2002
- Doctoral Scholarship:University of Bucharest, Faculty of Chemistry, Romania, 1999–2002
- European Community, TEMPUS-MS fellowship: Biosensors for Environmental Control, 1998


Research Interests

Analytical and bio-analytical chemistry, biosensors, biomaterials and bio-nanotechnology:

Fundamental research on biointerfaces, bioimmobilization and biomolecular recognition

Bioelectrochemistry and fundamental studies of nanoparticle reactivity by electrochemical collision at microelectrodes in colloidal dispersions

Biosensors for environmental, food and clinical monitoring

Portable nanoparticle based point-of-care diagnosis devices for low resource settings with main expertise on the use of ceria nanoparticles as colorimetric probes in bioanalysis

Paper based biosensors and multisensor arrays with printed enzymes and nanoparticles

Oxidative stress – development of methods for real time quantitative assessment of reactive oxygen and nitrogen species

Antioxidant and cytotoxic activity of engineered nanoparticles

Nanotoxicity – development of predictive tools and measurement technologies for in situ quantitative assessment of nanotoxic responses in vitro and in vivo

Microencapsulation of cells and enzymes for environmental bioremediation and in fermentation processes, in the production of bioethanol from cellulosic biomass

                                                

Current Research Funding

Title: Real-Time Monitoring of Neurotransmitters in a Hypoxic Environment
Agency: National Institutes of Health, NINDS, R21NS078738-01
Investigators: Emanuela S. Andreescu (PI)
Time period: 03/01/12 - 02/28/15

Title: Real Time Quantitative Assessment of Oxidative Stress as a Marker for Differential Nanoparticle Toxicity
Agency: National Science Foundation, CBET - 1336493
Investigators: Emanuela S. Andreescu (PI), Kenneth Wallace (co-PI)
Time period: 09/01/13 - 08/31/16

Title: Collaborative Research: Engineering Design of Oxygen Rich Surfaces for Bioelectrodes
Agency: National Science Foundation, CMMI -1200180
Investigators: Emanuela S. Andreescu (PI)
Time period: 12/01/12 - 01/01/16

Title: NSF-CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing Applications
Agency: National Science Foundation, DMR-0954919
Investigators: Emanuela S. Andreescu (PI)
Time period: 05/15/10 - 05/14/15

                                                  

Recent Peer Reviewed Publications

Probing phosphatase activity using redox active nanoparticles: a novel colorimetric approach for the detection of enzyme activity.  A. Hayat, G. Bulbul, S. Andreescu, Biosens. Bioelectron. In press, 2014.

Redox reactivity of cerium oxide nanoparticles against dopamine. A. Hayat, D. Andreescu, G. Bulbul, S. Andreescu, J. Colloid Interface Science 418, 2014, 240-245.

Metal oxide based multisensor array and portable database for field analysis of antioxidants, E. Sharpe, B. Bradley, T. Fresco, D. Jayathilaka, A. Marsh, S. Andreescu, Sensors & Actuators: B. Chemical. 193, 2014, 552-562.

Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments.  E. R. Ozel, C. Ispas, M. Ganesana, J. Leiter, S. Andreescu, Biosens. Bioelectron. 52, 2014, 397-402.

Electroanalytical evaluation of antioxidant activity of cerium oxide nanoparticles by nanoparticle collisions at microelectrodes. N. P. Sardesai, D. Andreescu, S. Andreescu, J. Am Chem. Soc. 135, 2014, 16770-16773.

Alterations of intestinal serotonin following nanoparticle exposure in embryonic zebrafish.  E. R. Ozel, K. Wallace, S. Andreescu, Environmental Science: Nano 1, 2014, 27-36.

Nanoceria particles as catalytic amplifiers for alkaline phosphatase assays.  A. Hayat, S. Andreescu, Anal. Chem. 85, 21, 2013, 10028-10032.

Effect of cerium oxide nanoparticles on intestinal serotonin in zebrafish.  E. R. Ozel, A. Hayat, K. Wallace, S. Andreescu, RSC Advances 3, 2013, 5298-15309.

Comparative Evaluation of Intestinal Nitric Oxide in Embryonic Zebrafish Exposed to Metal Oxide Nanoparticles.  E. R. Ozel, R. Alkasir, K. Ray, K. Wallace, S. Andreescu, Small  9, 24, 2013, 4250-4261.

Portable nanoparticle based technology for rapid detection of food antioxidants (NanoCerac).  E. Sharpe, T. Fresco, D. Andreescu, S. Andreescu, Analyst 138, 1, 2013, 249-262.

Colorimetric paper bioassay for the detection of phenolic compounds.  Ramiz S.J. Alkasir, M. Ornatska, S. Andreescu, Anal. Chem. 84, 2012, 9729-9737.

Real-time monitoring of superoxide accumulation and antioxidant activity in a brain slice model using an electrochemical cytochrome c biosensor.  M. Ganesana, J.S. Erlichman, S. Andreescu, Free Radical Biology & Medicine, 53, 2012, 2240-2249.

Site-specific immobilization of a (His)6-tagged acetylcholinesterase on nickel nanoparticles for highly sensitive toxicity biosensors.  M. Ganesana, G. Istabouille, J.L. Marty, T. Noguer, S. Andreescu, Biosens. Bioelectron. 30, 2011, 43-48.

Ceria nanoparticles as colorimetric probes in paper-based bioassays.  M. Ornatska, E. Sharpe, D. Andreescu, S. Andreescu, Anal. Chem. 83 (11), 2011, 4273–4280.

Chitosan functionalized carbon fiber microelectrodes for real-time in vivo detection of neurotransmitters in live embryonic zebrafish.   E. R. Ozel, K. Wallace, S. Andreescu, Anal. Chim Acta, 695, 2011, 89–95.

Adsorption of Arsenic by Iron Oxide Nanoparticles: A Versatile, Inquiry Based Laboratory for Undergraduate Science Course.  D VanDorn, M.T. Ravalli, M. M. Small, B. Hillery, S. Andreescu, J. Chem Edu. 88(8), 2011, 1119-1122.

Enzyme functionalized nanoparticles for electrochemical biosensors: a comparative study with applications for the detection of bisphenol A.  R. Alkasir, M. Ganesana, Y.H. Won, L Stanciu, S. Andreescu, Biosens. Bioelectron. 26, 2010, 43-49.

Electrochemical quantification of serotonin in the live embryonic zebrafish intestine, J. Njagi, M. Ball, K. Wallace, S. Andreescu.  Anal. Chem. 82 (5), 2010, 1822-1830.

Amperometric detection of dopamine in vivo with an enzyme based carbon fiber microbiosensor, J. Njagi, M. Chernov, J. Leiter, S. Andreescu, Anal. Chem. 82 (3), 2010, 989–996.

Biomagnetic capsules for easy removal of phenol and bisphenol A.  C. Ispas, M. Ravalli, A. Steere, S. Andreescu, Water Research 44, 2010, 1961–1969.

A Sensitive Electrochemical Sensor based on Chitosan and Electropolymerized Meldola Blue for Monitoring NO in Brain Slices. J. Njagi, J.S. Erlichman, J.W. Aston, J.C. Leiter, S. Andreescu, Sensors and Actuators B 143, 2, 2010, 673-680.

Biosensors: Toxicity Monitoring. M. Ornatska, M. Ganesana, S. Andreescu, Encyclopedia of Industrial Biotechnology, Wiley, ISBN: 978-0-471-79930-6, 2009.

Toxicity and developmental defects of different sizes and shape nickel nanoparticles in zebrafish. C. Ispas, D. Andreescu, A. Patel, D. Goia, S. Andreescu, K. Wallace, Environmental Science and Technology 43, 16, 2009, 6349-6356.

Enzyme functionalized mesoporous silica for bioanalytical applications. C. Ispas, I. Sokolov, S. Andreescu, Anal. Bioanal. Chem. 393, 2, 2009, 543-554.

Applications of advanced nanomaterials for environmental monitoring. S. Andreescu, J. Njagi, C. Ispas, M. Ravalli, J. Env. Monitoring 11, 2009, 27–40.

Magnetic Particles-Based Hybrid Platforms for Bioanalytical Sensors. L. Stanciu, Y.-H. Won, M. Ganesana, S. Andreescu, Sensors 9, 2009, 2976-2999.

Mixed Ceria Based Metal Oxides Biosensor for Operation in Oxygen Restrictive Environments. J. Njagi, C. Ispas, S. Andreescu, Anal. Chem. 80, 2008, 7266-7274.

Electrochemical Studies of ceria as electrode material for sensing and biosensing applications. C. Ispas, J. Njagi, M. Cates,* S. Andreescu, J. Electrochem. Soc. 155(8), 2008, F169-F176.

Studies of the Binding and Signaling of Surface-immobilized Periplasmic Glucose Receptors on Gold Nanoparticles: A Glucose Biosensor Application. S. Andreescu, L.A. Luck, Anal. Biochem. 375, 2008, 282-290.

Stable enzyme biosensors based on chemically synthesized Au-polypyrrole nanocomposite. J. Njagi, S. Andreescu, Biosens. Bioelectron.23, 2, 2007, 768-775.

 

Books Edited

Nanotechnology for Environmental Decontamination, McGraw-Hill (ISBN 0071702792), Ed: M.K. Ram, S. Andreescu, H. Ding, 448 pages, May, 2011.

Oxidative Stress: Diagnostics, Prevention, and Therapy, Oxford University Press. ACS symposium Series, Ed: Silvana Andreescu, Maria Hepel, Volume 1083, November 17, 2011, American Chemical Society, ISBN13: 9780841226838, eISBN: 9780841226845, DOI: 10.1021/bk-2011-1083. (http://pubs.acs.org/isbn/9780841226838).

Book1 book2

Patents

E.S. Andreescu, M. Ornatska, C. Ispas, D. Andreescu, Reagentless ceria based colorimetric sensor: colorimetric components, methods of use, methods of assembly and related applications, Patent Application, US20120315659WO2012170851A3, December 12, 2012, Appl # PCT/US2012/041608.

E.S. Andreescu, J. C. Leiter, J. S. Erlichman, Method of neuroprotection from oxidant injury using metal oxide nanoparticles, US Patent Application, US 2010/0098768, April 22, 2010.

E.S. Andreescu, E. Sharpe, D. Andreescu, Portable nanoparticle based assay for rapid detection of food antioxidants (NANOCERAC), Patent Application # 13/156,755, June 2011.

 

GROUP MEMBERS

Research Associates, Postdoctoral Fellows and Visiting Faculty

  • Dr. Naimish P. Sardesai (2012 – present)
  • Dr. Mouna Marrakhi (2013 - 2014), Fulbright Visiting Fellow, Carthage University, INSAT, Tunisia
  • Dr. Akhtar Hayat (2012 - 1013), currently Assistant Professor at COMSATS Institute of Information Technology (CIIT), Lahore, Pakistan
  • Dr. Maryna Ornatska (2008 - 2011), currently Senior Scientist at Elementis Specialties. Inc.


Current Graduate Students

  • Emrah Ozel
  • Erica Sharpe
  • Ramiz Alkassir
  • Xiaobo Liu
  • Gonca Bulbul
  • Anahita Karimi

 

Graduate Students - Alumni

  • Malli Ganesana, PhD 2011 – Postdoc at Dartmouth College
  • Cristina R. Ispas, PhD 2010 – Senior Scientist at Beckman Coulter, CA
  • John I. Njagi, PhD 2009 – Postdoc at Clarkson
  • Brian J. Frederick, MS 2009 - Research Assistant II at The Wistar Institute
  • Matthew T. Ravalli, MS 2009 – Research Assistant at Rensselaer Polytechnic Institute